Evidence map›Paper›PMID 41446263›Full record

ArticlebioRxiv : the preprint server for biology2025

The Binding Landscape of an Essential Nuclear Hormone Receptor in

Alexander L Sinks, Masako Asahina, Keith R Yamamoto, Jordan D Ward, Deborah M Thurtle-Schmidt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander L SinksBiology Department, Davidson College, Davidson, NC 28031.
Masako AsahinaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143.ORCID 0000-0001-9447-735X
Keith R YamamotoDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143.
Jordan D WardDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0001-9870-8936
Deborah M Thurtle-SchmidtBiology Department, Davidson College, Davidson, NC 28031.ORCID 0000-0002-9747-9585

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms of nematode moltingR01GM138701 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2020 to 2024
$1.6M
Mechanisms of nematode moltingR35GM158317 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Jordan David Ward · 2025 to 2026
$764k
Transcriptional networks controlling molting in C. elegans and B. malayiR00GM107345 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2017 to 2019
$747k
Genomic Analysis into Transcriptional Regulation of Cell IdentityR15GM147889 · NIGMS · DAVIDSON COLLEGE · PI THURTLE-SCHMIDT, DEBORAH · 2022 to 2022
$381k
Transcriptional networks controlling molting in C. elegans and B. malayiK99GM107345 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WARD, JORDAN DAVID · 2014 to 2015
$180k
NIGMS NIH HHS K99 GM107345NIGMS NIH HHS R00 GM107345NIGMS NIH HHS R01 GM138701NIGMS NIH HHS R15 GM147889NIGMS NIH HHS R35 GM158317NIH HHS P40 OD010440
6 · The paper itself

Abstract

Transcription factors (TFs) control gene expression by binding to response elements but distinguishing functional binding sites from non-functional ones remains a major challenge in the field of transcriptional regulation. To probe transcription factor binding and function in a multicellular organism we characterized the binding and transcriptional landscape of NHR-25, a highly-conserved and essential transcription factor in

Identifiers

PMID41446263
PMCPMC12724403

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.