ArticlebioRxiv : the preprint server for biology2025
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Astrocytes of the central nervous system have an intricate and highly branched morphology. Proper development of perisynaptic astrocyte processes is necessary for the tripartite synapse development, maturation, and function. However, how astrocyte morphogenesis is controlled, and the specific molecules orchestrating this development are largely unknown. Previously, we identified Neuroligins (NLs) 1-3 as regulators of astrocyte morphogenesis by forming transcellular adhesions with neuronal neurexins. Here, we found that NL2 plays a non-redundant essential role in astrocyte morphogenesis. Through structure and function studies, we identified a WW-binding motif within the NL2 intracellular domain required for astrocyte morphogenesis. Using cell-specific
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