Evidence map›Paper›PMID 41446245›Full record

ArticlebioRxiv : the preprint server for biology2025

Immune-mediated Engagement of T Regulatory Cells with Tumor Cells Results in Trogocytosis and Tumor Cell Killing.

Amy K Erbe, Arika S Feils, Anqi Gao, Sabrina N VandenHeuvel, Simon Boyenga, Alina Hampton, Mackenzie Heck, Jen Zaborek, Daniel Spiegelman, Noah Tsarovsky and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Amy K ErbeDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0003-1175-4062
Arika S FeilsDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-9349-4534
Anqi GaoDepartment of Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-8383-4283
Sabrina N VandenHeuvelDepartment of Human Oncology, University of Wisconsin, Madison WI.
Simon BoyengaDepartment of Human Oncology, University of Wisconsin, Madison WI.
Alina HamptonDepartment of Human Oncology, University of Wisconsin, Madison WI.
Mackenzie HeckDepartment of Human Oncology, University of Wisconsin, Madison WI.
Jen ZaborekDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison WI.
Daniel SpiegelmanDepartment of Human Oncology, University of Wisconsin, Madison WI.
Noah TsarovskyDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0001-9036-3515
Anna HoefgesDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-3712-4854
Alexander A PieperDepartment of Human Oncology, University of Wisconsin, Madison WI.
Peter M CarlsonDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0003-1908-7233
Mildred FelderDepartment of Human Oncology, University of Wisconsin, Madison WI.
Ravi B PatelUniversity of Pittsburgh, Pittsburgh PA.
Stephen D GilliesPineTree Therapeutics Inc. Carlisle, MA.ORCID 0000-0002-2080-4220
Alexa HeatonDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0003-4144-5535
Zachary MorrisDepartment of Human Oncology, University of Wisconsin, Madison WI.
Huy Q DinhDepartment of Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-3307-1126
Alexander L RakhmilevichDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-2686-9500
Paul M SondelDepartment of Human Oncology, University of Wisconsin, Madison WI.ORCID 0000-0002-0981-8875

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIM, KYUNGMANN · 2020 to 2024
$12.5M
Enhancing Antibody-directed Innate Immunity to Improve Cancer OutcomeR35CA197078 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 2015 to 2021
$6.4M
Multi-color Benchtop Flow CytometerS10RR025483 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI BUSHMAN, WADE A · 2009 to 2009
$449k
NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520NCI NIH HHS R35 CA197078NCRR NIH HHS S10 RR025483
6 · The paper itself

Abstract

Despite advances in treatment, >50% of patients with advanced melanoma are unresponsive to current therapies. Using the B78-D14 melanoma model (GD2

Indexed as

CD4sEffector TregsImmunocytokineMelanomaMHC-IMHC-IIRadiationTregTrogocytosis

Identifiers

PMID41446245
PMCPMC12724454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.