Evidence map›Paper›PMID 41446234›Full record

ArticlebioRxiv : the preprint server for biology2025

RPE pseudopods maintain photoreceptor outer segment renewal despite subretinal space expansion in

Tylor R Lewis, Carson M Castillo, Sebastien Phan, Camilla R Shores, Kylie K Hayase, Keun-Young Kim, Mark H Ellisman, Oleg Alekseev, Marie E Burns, Vadim Y Arshavsky

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tylor R LewisDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC.
Carson M CastilloDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC.
Sebastien PhanNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA.
Camilla R ShoresDepartment of Cell Biology and Human Anatomy, University of California Davis, Davis, CA.
Kylie K HayaseDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC.
Keun-Young KimNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA.
Mark H EllismanNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA.
Oleg AlekseevDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC.
Marie E BurnsDepartment of Cell Biology and Human Anatomy, University of California Davis, Davis, CA.
Vadim Y ArshavskyDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4M
Microglial Activation during Photoreceptor DegenerationR01EY024320 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BURNS, MARIE E · 2015 to 2024
$3.7M
Mechanisms of photoreceptor disc maturationR01EY030451 · NEI · DUKE UNIVERSITY · PI ARSHAVSKY, VADIM Y · 2020 to 2024
$2.4M
200keV, Energy Filtered, Intermediate-High Voltage Transmission Electron Microscope(IVEM)"S10OD034447 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2023 to 2023
$2.0M
Role of Proteasome Overload in Pathogenesis of Retinitis PigmentosaK08EY033857 · NEI · DUKE UNIVERSITY · PI Oleg Alekseev · 2022 to 2026
$854k
The role of ADAM9 in retinal health and diseaseR00EY033763 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Tylor Robert Lewis · 2024 to 2026
$747k
The role of ADAM9 in retinal health and diseaseK99EY033763 · NEI · DUKE UNIVERSITY · PI LEWIS, TYLOR ROBERT · 2022 to 2023
$252k
NEI NIH HHS K08 EY033857NEI NIH HHS K99 EY033763NEI NIH HHS P30 EY005722NEI NIH HHS R00 EY033763NEI NIH HHS R01 EY024320NEI NIH HHS R01 EY030451NIH HHS S10 OD034447NINDS NIH HHS U24 NS120055
6 · The paper itself

Abstract

Vision begins in the outer segment compartment of photoreceptor cells, which is constantly renewed through the addition of membrane material at its base and ingestion of mature membranes at its tip by the retinal pigment epithelium (RPE). The close apposition of outer segments to the RPE is believed to be critical for maintaining this renewal process. Yet, in several retinal diseases, expansion of the subretinal space separating photoreceptors from the RPE does not immediately impact photoreceptor functionality. Here, we analyzed outer segment function and renewal in the

Indexed as

ADAM9outer segmentphotoreceptorretinaRPEvision

Identifiers

PMID41446234
PMCPMC12724657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.