ArticlebioRxiv : the preprint server for biology2025
A thirty-year trend of increasing clinical orientation at the National Institutes of Health.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely recognized that funding for biomedical research supports the development of major medical advances. However, little systematic effort has been made to determine whether a link exists between the types of funding opportunities that are available to scientists and progress towards new treatments in the clinic. To better understand this relationship, we analyzed the funding opportunities offered by the National Institutes of Health (NIH) over a span of thirty-two years, together with the resulting portfolio of applications and awards. We found NIH funding opportunity announcements became more numerous and increasingly clinically oriented over that span, following a trend that parallels the increasing clinical and translational orientation of both NIH grant applications and NIH-funded publications. Surprisingly, this increase appears to be independent of the representation of clinician-scientists in the NIH workforce.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.