Evidence map›Paper›PMID 41446203›Full record

ArticlebioRxiv : the preprint server for biology2025

Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.

Dylan R Flink, Nicholas G Faturos, Haowei Zhang, Arif A Hamid

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dylan R FlinkDepartment of Neuroscience, University of Minnesota- Twin Cities, Minneapolis, MN.ORCID 0009-0000-1576-7528
Nicholas G FaturosGraduate Program in Neuroscience, University of Minnesota- Twin Cities, Minneapolis, MN.ORCID 0000-0002-3322-4081
Haowei ZhangGraduate Program in Neuroscience, University of Minnesota- Twin Cities, Minneapolis, MN.ORCID 0009-0009-6526-3913
Arif A HamidDepartment of Neuroscience, University of Minnesota- Twin Cities, Minneapolis, MN.ORCID 0000-0001-7403-0067

Funding

Using a computational and network neuroscience framework to study pharmacological manipulations of state representation processes in early psychosisP50MH119569 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH, Sophia Vinogradov · 2020 to 2026
$24.5M
Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
Medical Scientist Training ProgramT32GM156735 · NIGMS · UNIVERSITY OF MINNESOTA · PI YOJI SHIMIZU · 2025 to 2026
$2.6M
NIDA NIH HHS P30 DA048742NIDA NIH HHS T32 DA007234NIGMS NIH HHS T32 GM156735NIMH NIH HHS P50 MH119569
6 · The paper itself

Abstract

Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic interneurons (CINs) synapse onto DA axons and stimulate DA release via β

Identifiers

PMID41446203
PMCPMC12724702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.