Evidence map›Paper›PMID 41446191›Full record

ArticlebioRxiv : the preprint server for biology2025

The Lipid-binding PX Domain of RRC-1 (ARHGAP32/33) is Required for Optimal Assembly and Function of Integrin Adhesion Complexes at the Muscle Cell Boundary in C. elegans.

Sara Sagadiev, Isabel Martin, Nahum Arefeayne, Richard Yuchu Wang, Robert Hudson, Olga Mayans, Hiroshi Qadota, Guy M Benian

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sara SagadievDepartment of Pathology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-8371-0977
Isabel MartinDepartment of Biology, University of Konstanz, Konstanz, Germany.
Nahum ArefeayneDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Richard Yuchu WangDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Robert HudsonDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Olga MayansDepartment of Biology, University of Konstanz, Konstanz, Germany.
Hiroshi QadotaDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Guy M BenianDepartment of Pathology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-8236-3176

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
A Model Multi-systems Approach for Understanding the Role of the PIX Pathway in Cardiac Muscle and CardiomyopathyR01HL160693 · NHLBI · EMORY UNIVERSITY · PI BENIAN, GUY MARTIN · 2022 to 2025
$2.3M
NHLBI NIH HHS R01 HL160693NIGMS NIH HHS P41 GM103311NIH HHS P40 OD010440
6 · The paper itself

Abstract

Integrin adhesion complexes (IACs) are a network of many proteins that serve as anchors of the cell to the extracellular matrix (ECM). In muscle, IACs located at costameres, also serve to transmit the force of muscle contraction to the outside of the cell. We have reported that IACs, which are found at the bases of dense bodies and M-lines, and at muscle cell boundaries (MCB) in

Identifiers

PMID41446191
PMCPMC12724562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.