Evidence map›Paper›PMID 41446183›Full record

ArticlebioRxiv : the preprint server for biology2025

Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing.

Tianji Yu, Jimin Yoon, Yimeng Zhu, Angelina Li, Brian J Lee, Daniel F Moakley, Jing Duan, Qiannian Deng, Fanjia Hou, Mengfang Yan and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tianji YuDepartment of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Jimin YoonDepartment of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Yimeng ZhuInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Angelina LiInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Brian J LeeInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Daniel F MoakleyDepartment of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Jing DuanDepartment of Neurology, Shenzhen Children's Hospital, 7019# Yitian Road, Shenzhen, Guangdong, 518038, PR China.
Qiannian DengRare Disease Center, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China.
Fanjia HouInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518107, PR China.
Mengfang YanInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518107, PR China.
Vincenzo A GennarinoDepartment of Genetics and Development, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Ke ZhangRare Disease Center, Shenzhen Medical Academy of Research and Translation, Shenzhen, Guangdong 518107, PR China.
Li ChenDepartment of Neurology, Shenzhen Children's Hospital, 7019# Yitian Road, Shenzhen, Guangdong, 518038, PR China.
Shan ZhaInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-6568-1818
Chaolin ZhangDepartment of System Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-8310-7537

Funding

Complexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6M
RNA Regulatory Networks in Neuronal Cell Type Diversity and FunctionR01NS125018 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$3.0M
The non-catalytic function of PARP2 in DNA repair and cancer therapyR01CA271595 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2022 to 2026
$2.9M
The role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppressionR01CA275184 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA271595NCI NIH HHS R01 CA275184NIGMS NIH HHS R35 GM145279NINDS NIH HHS R01 NS125018
6 · The paper itself

Abstract

Accurate pre-mRNA splicing is essential for the transfer of genetic information but faces unique challenge in higher primates due to the massive expansion of intronic Alu elements

Identifiers

PMID41446183
PMCPMC12724504

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.