Evidence map›Paper›PMID 41446180›Full record

ArticlebioRxiv : the preprint server for biology2025

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation.

Samantha K Swift, Guangming Huang, J Nicholas Cochran, Miguel A Minaya, Patricia A Castruita, Katherine J Miller, Emma Starr, Grant Galasso, Jacob A Marsh, Aimee W Kao and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Samantha K SwiftDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-5618-7578
Guangming HuangDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, United States.ORCID 0000-0002-9852-5504
Miguel A MinayaDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2573-6087
Patricia A CastruitaEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0009-0006-7848-5177
Katherine J MillerDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Emma StarrDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Grant GalassoDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Jacob A MarshDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-3576-6949
Aimee W KaoEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Jennifer S YokoyamaEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0001-7274-2634
Celeste M KarchDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6854-5547

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2023 to 2026
$39.4M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A., KAO, AIMEE · 2021 to 2025
$9.0M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Elucidating clinical heterogeneity in early-onset AD via genomics, transcriptomics, and neuroimagingR01AG062588 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOKOYAMA, JENNIFER S · 2019 to 2023
$4.0M
Multidisciplinary Training in Alzheimer and Related DementiasT32AG058518 · NIA · WASHINGTON UNIVERSITY · PI Eric Martin McDade, Barbara Joy Snider · 2018 to 2026
$2.3M
Targeting Tau Proteoforms in Frontotemporal DementiaRF1NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2021 to 2021
$1.8M
Targeting Tau Proteoforms in Frontotemporal DementiaR01NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2024 to 2024
$575k
Targeting Tau Proteoforms in Frontotemporal DementiaR56NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2019 to 2019
$558k
NCATS NIH HHS UL1 TR002345NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG062588NIA NIH HHS T32 AG058518NIA NIH HHS U19 AG079774NIH HHS S10 OD030233NINDS NIH HHS R01 NS110890NINDS NIH HHS R56 NS110890NINDS NIH HHS RF1 NS110890NINDS NIH HHS U54 NS123985
6 · The paper itself

Abstract

Introduction: Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poorly understood. Methods: We integrated human genetics, transcriptomics, and functional studies to identify proteostasis network components involved in tauopathy. Results: We identified 18 proteostasis network genes harboring 75 rare, damaging variants enriched in FTD and/or AD. These genes, spanning multiple proteostasis pathways, were differentially expressed in Discussion: Our findings identify a set of proteostasis genes with genetic and transcriptional links to neurodegeneration and reveal

Indexed as

Alzheimer’s diseaseautophagy lysosomal pathwaybrain tissuefrontotemporal dementiafunctional genomicshuman geneticsNINLProteostasisstem cell modelsTautau aggregationtauopathy

Identifiers

PMID41446180
PMCPMC12724438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.