Evidence map›Paper›PMID 41446178›Full record

ArticlebioRxiv : the preprint server for biology2025

Absence of Mother's Curse for performance traits among divergent mtDNAs in heterozygous nuclear backgrounds in Drosophila.

David M Rand, Faye A Lemieux, Kenneth M Bradley, Lindsay Marmor, Leah J Darwin, Yevgeniy Raynes

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David M RandDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.ORCID 0000-0001-6817-3459
Faye A LemieuxDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.
Kenneth M BradleyDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.
Lindsay MarmorDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.
Leah J DarwinDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.ORCID 0000-0002-7060-2782
Yevgeniy RaynesDepartment of Ecology, Evolution and Organismal Biology, Brown University, Providence Rhode Island 02806.

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI WONG, IAN Y · 2016 to 2025
$22.6M
Nuclear-Mitochondrial Fitness Interactions in DrosophilaR01GM067862 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2004 to 2020
$5.1M
Mitonuclear genetics of complex traits in DrosophilaR35GM139607 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2021 to 2025
$1.9M
NIGMS NIH HHS P20 GM109035NIGMS NIH HHS R01 GM067862NIGMS NIH HHS R35 GM139607
6 · The paper itself

Abstract

Maternal inheritance allows selection to act on mtDNA-encoded effects in females but prevents direct selection on mtDNA in males. Mutations that are deleterious in males but neutral or beneficial in females can persist in populations. This predicts that mtDNA-based phenotypic variation should be more common among males than among females, a pattern referred to as Mother's Curse (MC). Most studies of MC place alternative mtDNAs on common homozygous nuclear chromosomal backgrounds, a condition not common in nature. Moreover, it is not known whether MC effects accumulate as mtDNAs acquire nucleotide substitutions between populations or species. We tested the MC hypothesis using mtDNAs from

Indexed as

Epistasisevolutionary geneticsMitonuclearQuantitative traitsSex specific selection

Identifiers

PMID41446178
PMCPMC12724570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.