Evidence map›Paper›PMID 41446171›Full record

ArticlebioRxiv : the preprint server for biology2025

Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease.

Ruby Gupta, Akash Chinchole, Ngozi P Paul, Mrinal K Sarkar, Johann E Gudjonsson, Ajay Verma, Rajini Rao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ruby GuptaDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore MD 21205.ORCID 0000-0001-8101-5930
Akash ChincholeDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore MD 21205.ORCID 0000-0003-0371-8811
Ngozi P PaulDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore MD 21205.ORCID 0000-0003-0423-195X
Mrinal K SarkarDepartment of Dermatology, Taubman Medical Research Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8505-4259
Johann E GudjonssonDepartment of Dermatology, Taubman Medical Research Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-0080-0812
Ajay VermaFormation Venture Engineering Foundry, 47 Fox Run Road, Topsfield MA.ORCID 0000-0001-7715-0443
Rajini RaoDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore MD 21205.ORCID 0000-0002-1833-5971

Funding

University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Towards a targeted therapy for Hailey Hailey DiseaseR03TR005427 · NCATS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2024 to 2024
$164k
NCATS NIH HHS R03 TR005427NIAMS NIH HHS P30 AR075043
6 · The paper itself

Abstract

Hailey Hailey Disease (HHD) is an autosomal dominant cutaneous disorder caused by mutations in

Indexed as

ATP2C1insulinlamellipodiaRac1secretory pathway calcium ATPasewound healing

Identifiers

PMID41446171
PMCPMC12724522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.