In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Christopher AugerDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0003-4207-9354 Hiroshi NishidaDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0003-0284-5771 Bo YuanDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, 02115.ORCID 0000-0003-0222-8095 Guilherme Martins SilvaCenter for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA, 02115.ORCID 0000-0002-7571-9090 Masanori FujimotoDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.
Mark LiDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.
Daisuke KatohDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0001-6576-0463 Dandan WangDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0009-0006-2788-7475 Melia Granath-PaneloDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0002-4609-2786 Jihoon ShinDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0003-1294-0238 Rose WitteDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0009-0003-9097-4334 Jin-Seon YookDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0002-9294-6770 Anthony R P VerkerkeDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0002-6198-4723 Alexander S BanksDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA, 02115.ORCID 0000-0003-1787-6925 Sheng HuiDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, 02115.ORCID 0000-0002-4226-6806 Lijun SunCenter for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA, 02115.ORCID 0000-0002-1579-2253 Shingo KajimuraDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA, 02115.ORCID 0000-0003-0672-5910 Funding
Molecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9MMitochondrial Metabolite Compartmentalization in Health and DiseaseDP1DK126160 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2025
$4.4MA liver-specific mitochondrial carrier that controls energy homeostasisR01DK138529 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Shingo Kajimura · 2024 to 2026
$2.1MInstrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737kFluxomics Studies of the Effect of Diet Composition on Energy MetabolismR56DK140139 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI HUI, SHENG · 2024 to 2024
$507kDefining choline metabolism in metabolic healthK01DK144653 · NIDDK · UNIVERSITY OF MINNESOTA · PI Anthony Verkerke · 2025 to 2026
$320kNIDDK NIH HHS DP1 DK126160NIDDK NIH HHS K01 DK144653NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK138529NIDDK NIH HHS R56 DK140139NIH HHS S10 OD028635
6 · The paper itselfAbstract
Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthesis from trimethyllysine (TML) is essential, particularly for those who consume plant-based diets; however, its molecular regulation and physiological role remain elusive. Here, we identify SLC25A45 as a mitochondrial TML carrier that controls carnitine biosynthesis and fuel switching. SLC25A45 deficiency decreased the carnitine pool and impaired mitochondrial fatty acid oxidation, shifting reliance to carbohydrate metabolism.
Identifiers
PMID41446161
PMCPMC12724661
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390