Evidence map›Paper›PMID 41446145›Full record

ArticlebioRxiv : the preprint server for biology2025

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening.

Chanhee Kim, Zhaohan Zhu, Abderrahmane Tagmount, W Brad Barbazuk, Rhonda Bacher, Christopher D Vulpe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Chanhee KimCenter for Human and Environmental Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.
Zhaohan ZhuDepartment of Biostatistics, University of Florida, FL, United States.
Abderrahmane TagmountCenter for Human and Environmental Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.
W Brad BarbazukDepartment of Biology, University of Florida, FL, United States.
Rhonda BacherDepartment of Biostatistics, University of Florida, FL, United States.ORCID 0000-0001-5787-476X
Christopher D VulpeCenter for Human and Environmental Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, United States.

Funding

Supplement: CRISPR screens of population relevant genes governing toxicant resilienceR01ES033625 · NIEHS · UNIVERSITY OF FLORIDA · PI CHRISTOPHER D VULPE · 2022 to 2026
$4.1M
NIEHS NIH HHS R01 ES033625
6 · The paper itself

Abstract

Many omics-based approaches in toxicology research primarily rely on correlative data, often lacking functional relationships or causal links between genotypes and phenotypes. CRISPR-based approaches can overcome this limitation by establishing direct causal connections between genes and toxicological phenotypes. Moreover, CRISPR screens enable scalable and systematic interrogation of gene function and associated mechanisms following chemical exposure, predominantly using

Indexed as

3D CRISPR screeninganthracyclineschemical toxicitydoxorubicinfunctional toxicogenomicsgenetic variabilityNAMsspheroid

Identifiers

PMID41446145
PMCPMC12724170

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.