Evidence map›Paper›PMID 41446134›Full record

ArticlebioRxiv : the preprint server for biology2025

Eraj S Khokhar, Kaitlyn Brokaw, Zachary J Kartje, Marina Krykbaeva, Ezequiel Calvo-Roitberg, Adam K Hedger, Jonathan Lee, Atish Wagh, Jonathan K Watts, Athma A Pai

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eraj S KhokharRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-0713-7099
Kaitlyn BrokawRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-8056-7108
Zachary J KartjeRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0001-9798-8382
Marina KrykbaevaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.
Ezequiel Calvo-RoitbergRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-2431-515X
Adam K HedgerRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0003-1529-2598
Jonathan LeeRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.
Atish WaghRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-1275-1341
Jonathan K WattsRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0001-5706-1734
Athma A PaiRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-7995-9948

Funding

Next-generation antisense therapeutics for ALS and frontotemporal dementiaR01NS111990 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Robert H Brown, Jonathan K Watts · 2019 to 2026
$5.2M
Tracking transcriptome diversity in real-timeR35GM133762 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Athma A Pai · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133762NINDS NIH HHS R01 NS111990
6 · The paper itself

Abstract

Cryptic splicing has emerged as a pervasive feature of mammalian gene expression, with recent studies uncovering thousands of previously unannotated splice sites. Despite its prevalence, the functional consequences of this hidden layer of splicing remain largely unknown due to challenges in identifying the exact exonic regions introduced into mRNA transcripts. Here, we introduce a novel computational approach,

Identifiers

PMID41446134
PMCPMC12724713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.