Evidence map›Paper›PMID 41446101›Full record

ArticlebioRxiv : the preprint server for biology2025

A single-cell cytokine dictionary of human peripheral blood.

Lukas Oesinghaus, Sören Becker, Larsen Vornholz, Efthymia Papalexi, Joey Pangallo, Amir Ali Moinfar, Jenni Liu, Alyssa La Fleur, Maiia Shulman, Simone Marrujo and 18 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Lukas OesinghausDepartment of Electrical and Computer Engineering, University of Washington, Seattle, USA.ORCID 0000-0002-5464-1044
Sören BeckerInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0001-5318-9730
Larsen VornholzInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0002-8054-5603
Efthymia PapalexiParse Biosciences, Seattle, USA.ORCID 0000-0001-5898-694X
Joey PangalloParse Biosciences, Seattle, USA.ORCID 0009-0009-4787-8383
Amir Ali MoinfarInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0009-0005-4680-2724
Jenni LiuInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0009-0009-0156-3079
Alyssa La FleurPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, USA.
Maiia ShulmanInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0009-0006-6308-1997
Simone MarrujoParse Biosciences, Seattle, USA.ORCID 0009-0005-8169-5936
Bryan HariadiParse Biosciences, Seattle, USA.ORCID 0009-0008-3498-3996
Crina CurcaParse Biosciences, Seattle, USA.ORCID 0009-0005-7594-2144
Alexa SuyamaParse Biosciences, Seattle, USA.ORCID 0000-0002-0571-0808
Maria NigosParse Biosciences, Seattle, USA.
Oliver SandersonParse Biosciences, Seattle, USA.
Hoai NguyenParse Biosciences, Seattle, USA.
Vuong K TranParse Biosciences, Seattle, USA.ORCID 0000-0002-2564-0202
Ajay A SapreParse Biosciences, Seattle, USA.ORCID 0000-0001-7174-2480
Olivia KaplanParse Biosciences, Seattle, USA.
Sarah SchroederParse Biosciences, Seattle, USA.
Alec SalvinoParse Biosciences, Seattle, USA.
Guillermo Gallareta-OlivaresParse Biosciences, Seattle, USA.
Ryan KoehlerParse Biosciences, Seattle, USA.ORCID 0000-0001-6340-7674
Gary GeissParse Biosciences, Seattle, USA.
Alexander B RosenbergParse Biosciences, Seattle, USA.ORCID 0000-0003-2276-2412
Charles M RocoParse Biosciences, Seattle, USA.ORCID 0000-0002-6493-000X
Georg SeeligDepartment of Electrical and Computer Engineering, University of Washington, Seattle, USA.ORCID 0000-0002-3163-8782
Fabian J TheisInstitute of Computational Biology, Helmholtz Center Munich, Munich, Germany.ORCID 0000-0002-2419-1943

Funding

Engineering cell type-specific splicing regulationR01GM149631 · NIGMS · UNIVERSITY OF WASHINGTON · PI Georg Seelig · 2023 to 2026
$1.5M
Decode polyadenylation in health and diseaseR01CA297834 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yongsheng Shi · 2025 to 2026
$1.3M
Sequence optimization for mRNA cancer therapyR33CA286947 · NCI · UNIVERSITY OF WASHINGTON · PI Georg Seelig · 2025 to 2026
$760k
NCI NIH HHS R01 CA297834NCI NIH HHS R33 CA286947NIGMS NIH HHS R01 GM149631
6 · The paper itself

Abstract

Cytokines orchestrate immune responses, yet we still lack a comprehensive understanding of their specific effects across human immune cells due to their pleiotropy, context dependence and extensive functional redundancy. Here, we present a Human Cytokine Dictionary, created from high-resolution single-cell transcriptomes of 9,697,974 human peripheral blood mononuclear cells (PBMC) from 12 donors stimulated

Identifiers

PMID41446101
PMCPMC12724453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.