Evidence map›Paper›PMID 41446098›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice.

Dantong Zhu, Shyleen Frost, Patrick Griffin, Maeve McNamara, David A Sinclair, Alice E Kane

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dantong ZhuInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0003-0875-0490
Shyleen FrostInstitute for Systems Biology, Seattle, WA 98109, USA.
Patrick GriffinBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02115, USA.
Maeve McNamaraBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02115, USA.
David A SinclairBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02115, USA.
Alice E KaneInstitute for Systems Biology, Seattle, WA 98109, USA.ORCID 0000-0002-4303-0491

Funding

Role of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3M
Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic DeterminantsR00AG070102 · NIA · INSTITUTE FOR SYSTEMS BIOLOGY · PI KANE, ALICE E · 2023 to 2025
$1.0M
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurementR21HG011850 · NHGRI · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2021 to 2021
$626k
NHGRI NIH HHS R21 HG011850NIA NIH HHS R00 AG070102NIA NIH HHS R01 AG019719
6 · The paper itself

Abstract

Frailty is an age-related geriatric syndrome with largely unknown mechanisms. We conducted a longitudinal study of aging C57BL/6JNIA mice (females;

Indexed as

AgingDNA methylationEpigeneticsFrailtyLongitudinalMiceSex differences

Identifiers

PMID41446098
PMCPMC12724424

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.