Evidence map›Paper›PMID 41446090›Full record

ArticlebioRxiv : the preprint server for biology2025

Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity.

Jessica R Lane, Henry Mauser, Silvia E Santana-Krímskaya, Vahini S Konda, Andrew DePass, Giuseppe Ercoli, Federico I Prokopczuk, Mohammed Mohasin, Adonis D'Mello, Hervé Tettelin and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jessica R LaneDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Henry MauserDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Silvia E Santana-KrímskayaDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Vahini S KondaDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Andrew DePassDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Giuseppe ErcoliCentre for Inflammation and Tissue Repair, Division of Medicine, University College of London, London, United Kingdom.
Federico I ProkopczukDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mohammed MohasinDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Adonis D'MelloInstitute for Genome Sciences, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Hervé TettelinInstitute for Genome Sciences, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0615-3257
Jeremy S BrownCentre for Inflammation and Tissue Repair, Division of Medicine, University College of London, London, United Kingdom.
Luis F ReyesUnisabana Center for Translational Science, Universidad de La Sabana, Chia, Colombia.
Carlos J OrihuelaDepartment of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-8542-4069

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
Cardiac microlesion formation during invasive pneumococcal diseaseR01AI114800 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Carlos J Orihuela, Herve S TETTELIN · 2015 to 2026
$5.1M
PspA binds necroptotic cells to cause disease and transmitR01AI156898 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ORIHUELA, CARLOS J · 2020 to 2024
$2.0M
Biofilm antigens drive natural immunity to Streptococcus pneumoniae.F31AI186511 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LANE, JESSICA R · 2024 to 2025
$86k
NIAID NIH HHS F31 AI186511NIAID NIH HHS R01 AI114800NIAID NIH HHS R01 AI156898NIAID NIH HHS T32 AI007051Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41446090
PMCPMC12724463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.