Evidence map›Paper›PMID 41446079›Full record

ArticlebioRxiv : the preprint server for biology2025

Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model.

Iman Hassani, Benjamin Anbiah, Yuan Tian, Bulbul Ahmed, William J Van Der Pol, Elliot J Lefkowitz, Peyton Kuhlers, Nicole L Habbit, Martin J Heslin, Michael W Greene and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Iman HassaniDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-5943-3984
Benjamin AnbiahDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-0993-3037
Yuan TianDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.
Bulbul AhmedDepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USA.
William J Van Der PolCenter for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL, United States 35233, USA.
Elliot J LefkowitzCenter for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL, United States 35233, USA.ORCID 0000-0002-4748-4925
Peyton KuhlersDepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USA.
Nicole L HabbitDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-9293-1325
Martin J HeslinDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States 35233, USA.ORCID 0000-0002-9932-2362
Michael W GreeneDepartment of Nutritional Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-6443-8269
Elizabeth A LipkeDepartment of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-3465-5609

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Engineered Colon Cancer Tissue to Examine the Role of the Obese Microenvironment in Tumor AggressivenessR01CA267170 · NCI · AUBURN UNIVERSITY AT AUBURN · PI Michael W Greene, Elizabeth A Lipke · 2022 to 2026
$2.6M
NCATS NIH HHS UL1 TR001417NCATS NIH HHS UL1 TR003096NCI NIH HHS R01 CA267170
6 · The paper itself

Abstract

Establishing

Indexed as

cancer tissue engineeringcolon cancerorganoidPDXstiffnesstumor microenvironment

Identifiers

PMID41446079
PMCPMC12724408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.