Evidence map›Paper›PMID 41446064›Full record

ArticlebioRxiv : the preprint server for biology2025

Temporal single-cell analysis reveals age-associated delay in immune resolution after respiratory viral infection.

Yue Wu, Chaofan Li, Jinyi Tang, Xiaochen Gao, In Su Cheon, Bibo Zhu, Ruixuan Zhang, Cori E Fain, Shengen Shawn Hu, Harish Narasimhan and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yue WuBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Chaofan LiBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Jinyi TangBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Xiaochen GaoDepartment of Immunology, Mayo Clinic; Rochester, MN 55905, USA.
In Su CheonBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Bibo ZhuBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Ruixuan ZhangBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Cori E FainDepartment of Immunology, Mayo Clinic; Rochester, MN 55905, USA.
Shengen Shawn HuDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Harish NarasimhanBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Gislane de Almeida SantosBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic; Rochester, MN 55905, USA.
Aaron J JohnsonDepartment of Immunology, Mayo Clinic; Rochester, MN 55905, USA.
Hui ZongDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia; Charlottesville, VA 22908, USA.ORCID 0000-0002-4263-9633
Chongzhi ZangDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0003-4812-3627
Haidong DongDepartment of Immunology, Mayo Clinic; Rochester, MN 55905, USA.ORCID 0000-0002-5782-2983
Jie SunBeirne B. Carter Center for Immunology Research, University of Virginia; Charlottesville, VA 22908, USA.ORCID 0000-0002-2347-4511

Funding

Host cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7M
Elucidating the roles of alveolar macrophage inflammation and selfrenewal during influenza infectionR01AG069264 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$3.5M
Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with AsthmaR01AI176171 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun, WILLIAM GERALD TEAGUE · 2023 to 2026
$2.7M
Uncover mechanisms underlying the development of chronic lung sequelae post COVID-19R01HL170961 · NHLBI · UNIVERSITY OF VIRGINIA · PI Jie Sun, ROBERT VASSALLO · 2023 to 2026
$2.7M
CD38, T cells and post viral lung sequelae during agingR01AG090337 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL170961NIAID NIH HHS R01 AI147394NIAID NIH HHS R01 AI176171NIA NIH HHS R01 AG069264NIA NIH HHS R01 AG090337
6 · The paper itself

Abstract

Aging is a major risk factor for increased morbidity and mortality following acute respiratory virus infections. To elucidate the immune determinants underlying viral pathogenesis and delayed lung repair in the aged lung, a comprehensive time-course study was conducted. Single-cell RNA sequencing (scRNAseq) and high-dimensional flow cytometry were utilized to compare lungs from young and aged mice infected with influenza A virus (IAV). Aged hosts displayed diminished alveolar macrophage (AM) and dendritic cell (DC) but elevated monocyte-derived macrophage (MoM) and interstitial macrophage (IM) presence following infection. Additionally, enhanced accumulation of adaptive immune cells, including CD4

Indexed as

AgingChronic DiseaseInfluenza A VirusSingle-Cell Analysis

Identifiers

PMID41446064
PMCPMC12724688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.