Evidence map›Paper›PMID 41446057›Full record

ArticlebioRxiv : the preprint server for biology2026

EMPIRICAL VALIDATION OF THE NEARLY NEUTRAL THEORY AT DIVERGENCE AND POPULATION GENOMIC SCALE USING 144 PLACENTAL MAMMALS GENOMES.

M Bastian, D Enard, N Lartillot

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

M BastianLaboratoire de Biométrie et Biologie Evolutive, UMR5558, Usniversité Lyon 1, Villeurbanne, France.ORCID 0009-0003-9129-6918
D EnardDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85719, USA.ORCID 0000-0003-2634-8016
N LartillotLaboratoire de Biométrie et Biologie Evolutive, UMR5558, Usniversité Lyon 1, Villeurbanne, France.ORCID 0000-0002-9973-7760

Funding

Ancient viral threats through the lens of adaptation in human genomesR35GM142677 · NIGMS · UNIVERSITY OF ARIZONA · PI ENARD, DAVID · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142677
6 · The paper itself

Abstract

By limiting the efficacy of selection, random drift is expected to play a major role in genome evolution. Formalizing this idea, the nearly-neutral theory predicts that the ratio of non-synonymous over synonymous polymorphism

Indexed as

effective population sizegenetic driftmammalsmicro-macro evolutionphylogenomicpopulation genomicselection efficacy

Identifiers

PMID41446057
PMCPMC12724173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.