Evidence map›Paper›PMID 41445991›Full record

ReviewCureus2025

Anatomical and Functional Changes After Surgical Treatment of Carpal Tunnel Syndrome: A Review.

Evangelos E Tzanis, John Vlamis, Sophia A Syngouna, Evangelos Sakellariou, Angeliki Kyriakou, Loukia Fragkopoulou

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evangelos E Tzanis3rd Orthopaedic Department, KAT Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
John Vlamis3rd Orthopaedic Department, KAT Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Sophia A SyngounaDepartment of Hand-Upper Limb and Microsurgery, KAT Hospital, Kifisia, GRC.
Evangelos Sakellariou3rd Orthopaedic Department, KAT Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Angeliki KyriakouDepartment of Hand-Upper Limb and Microsurgery, KAT Hospital, Kifisia, GRC.
Loukia FragkopoulouDepartment of Radiology, KAT Hospital, Kifisia, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carpal tunnel syndrome (CTS) is a common condition resulting from the compression of the median nerve within the carpal tunnel (CT), leading to sensory and motor deficits in the hand. This review synthesizes current literature on the anatomical and functional changes following surgical intervention for CTS. Surgical treatment, primarily through carpal tunnel release (CTR), has been shown to alleviate symptoms for many patients; however, variability exists regarding the extent of anatomical recovery and functional improvement. Analyzing key studies, we observe that while most patients experience significant relief from pain and sensory symptoms, some may continue to report functional limitations. The prevailing conclusion is that while surgical intervention addresses compression, the extent of anatomical recovery, such as nerve conduction velocity and morphological changes in hand structure, remains underexplored. The evidence indicates that although surgical treatment generally yields positive outcomes, it often falls within the framework of statistical analysis that relies on reported outcomes without rigorous control measures. As such, further controlled studies are necessary to better elucidate the relationship between anatomical alterations and functional recovery post-surgery. The review emphasizes the need for a comprehensive approach in future research that not only focuses on statistical outcomes but also incorporates qualitative assessments of patient functionality and anatomical restoration. Ultimately, a deeper understanding of these domains will enhance the predictive models for recovery and guide clinical practices for individuals suffering from CTS. This analysis seeks to bridge existing gaps and inspire future studies aimed at optimizing therapeutic strategies for CTS.

Indexed as

anatomical changescarpal tunnel syndromeconservative surgicaldiagnosisepidemiologypathophysiologypostoperative recoveryrisk factorssymptomstreatment

Identifiers

PMID41445991
PMCPMC12723553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.