ArticleNeurology. Clinical practice2026
Advancing Early Detection of Alzheimer Disease in the Primary Care Setting in the United States.
Article in Neurology. Clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Adoption of Alzheimer's disease biomarkers by primary care clinicians: findings from the National Dementia Workforce Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Comment on "The value of cholinesterase inhibitors for improving neuropsychiatric and functional assessment scores in patients with Alzheimer disease: a systematic review and meta-analysis of on placebo-controlled RCTs".International journal of surgery (London, England) · 2026Article
- Willingness and barriers to blood-based biomarker testing of Alzheimer's disease in the general population in the Czech Republic.Alzheimer's research & therapy · 2026Article
- System changes to empower primary care in Alzheimer's disease detection and care.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Uncovering barriers to early diagnosis of Alzheimer's disease: a European perspective.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: As evidence supporting the robustness of blood-based biomarker (BBM) testing for Alzheimer disease (AD) continues to emerge, understanding the perceptions, drivers, and barriers to the adoption of these tests among primary care physicians (PCPs) in the United States is crucial for improving patient outcomes and advancing clinical management of AD. In this study, we perform a survey of PCPs in the United States to better understand current practices for detecting and diagnosing mild cognitive impairment (MCI) or mild dementia due to AD and to identify drivers and barriers to adopting BBM testing in primary care clinics in the United States. Methods: This was a cross-sectional study involving a self-administered quantitative online survey. An advisory board was convened before and after the survey to advise on the survey design and discuss survey results. The survey was conducted online in the United States between December 2023 and January 2024, excluding Vermont and Maine because of state laws restricting PCP participation in market research. A total of 603 PCPs from the United States completed the survey for their self-reported perception and adoption of BBM tests for early diagnosis of AD, including awareness and/or experience with testing for patients with suspected cognitive/memory issues, and their belief, motivation, and obstacles for ordering BBM tests. Results: Lack of effective diagnostic tools in the primary care setting and recognition of MCI/early AD symptoms were among the top barriers to early diagnosis of MCI/mild dementia due to AD. Although PCPs manage or treat patients with MCI/mild dementia independently, awareness and adoption of AD BBM tests are substantially lower (<15%) compared with standard cognitive assessments and non-AD-specific blood tests (>65%). Despite practice and perception barriers, two-thirds of PCPs reported that they would order a BBM test for patients with cognitive concerns to improve the diagnosis and management of AD. However, concerns were raised regarding testing accuracy, financial burden, and reimbursement. Discussion: Primary care physicians are willing to adopt blood-based biomarker tests for diagnosing MCI and mild dementia due to AD, provided that they receive enhanced education, clear guidelines, and reimbursement support.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.