ArticleSouth Asian journal of cancer2025
Evaluation of the Efficacy of Romiplostim in Management of Chemotherapy-Induced Thrombocytopenia in Indian Patients: A Retrospective Study.
Article in South Asian journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Chemotherapy-induced thrombocytopenia (CIT) is a frequent complication of antineoplastic therapy. The incidence of CIT varies with cancer type and regimen used. CIT can result in chemotherapy delays, dose reductions, and discontinuation, leading to reduced survival rates· Romiplostim is a thrombopoietin receptor agonist that is effective for the treatment of CIT. Aim: This article evaluates the efficacy and safety of romiplostim in patients with CIT in a real-world setting. Methodology: The study was a retrospective, single-center study, which enrolled patients with solid tumors or hematological malignancies with persistent thrombocytopenia who had been treated with romiplostim. Results: A total of 100 patients with CIT were categorized into three treatment groups: romiplostim 500 mcg ( Conclusion: Romiplostim was effective in increasing platelet counts regardless of the grade of thrombocytopenia. Romiplostim use for the management of CIT will help in correcting CIT and allow resumption of chemotherapy without recurrence of CIT in most patients undergoing cancer chemotherapy.
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