ArticleClinical, cosmetic and investigational dermatology2025
DNA Methylation-Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Emerging evidence suggests that protein palmitoylation plays a critical role in regulating cellular signaling, yet its involvement in skin aging remains largely unexplored. Additionally, the epigenetic regulation of palmitoylation-related genes in age-related dermal changes has not been systematically studied. This research aimed to investigate the causal relationship between palmitoylation genes, DNA methylation, and facial skin aging using Mendelian randomization (MR) methods. Methods: We performed an integrated genetic analysis using two-sample MR and summary-data-based MR (SMR) to identify palmitoylation-related genes with a potential causal role in facial skin aging. For significant genes, we further conducted a two-step MR mediation analysis to investigate whether DNA methylation influences facial aging by altering these palmitoylation genes, complemented by sensitivity tests to evaluate the robustness of findings. Analyses utilized large-scale datasets, including facial aging genome-wide association study (GWAS) summary statistics (n = 423,992), gene expression data from eQTLGen, and methylation profiles from GoDMC. Results: The initial two-sample MR identified a significant positive association between ZDHHC17 expression and facial aging risk ( Conclusion: Collectively, this study offers new insights into the molecular mechanisms of skin aging and highlights ZDHHC17 methylation as a potential biomarker or therapeutic target in age-related dermatological intervention.
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