Evidence map›Paper›PMID 41445840›Full record

ArticleNeurobiology of language (Cambridge, Mass.)2025

Neural Predictors for the Generalization of Semantic and Phonological Treatment to Discourse Performance in Chronic Post-Stroke Aphasia.

Laura Giglio, Leonardo Bonilha, Julius Fridriksson, Sigfus Kristinsson, Roger Newman-Norlund, Chris Rorden, Brielle C Stark, Janina Wilmskoetter, Dirk B den Ouden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of language (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura GiglioDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0001-5369-4331
Leonardo BonilhaDepartment of Neurology, School of Medicine, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-6153-8942
Julius FridrikssonDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0001-9255-2045
Sigfus KristinssonDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-0459-5369
Roger Newman-NorlundDepartment of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-0966-1070
Chris RordenDepartment of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-7554-6142
Brielle C StarkDepartment of Speech, Language and Hearing Sciences, Program for Neuroscience, Indiana University Bloomington, Bloomington, IN, USA.ORCID https://orcid.org/0000-0002-7001-8324
Janina WilmskoetterDepartment of Health and Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID https://orcid.org/0000-0002-1083-7301
Dirk B den OudenDepartment of Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID https://orcid.org/0000-0001-6971-7606

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2016 to 2025
$25.0M
RHDBank Database DevelopmentR01DC008524 · NIDCD · CARNEGIE-MELLON UNIVERSITY · PI BRIAN MACWHINNEY · 2007 to 2026
$7.0M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC008524
6 · The paper itself

Abstract

Recovery of language function in post-stroke aphasia is affected by many variables, including aphasia severity, age, lesion site and size, and brain health. Semantic and phonological therapies are often used to target naming abilities, and when successful their benefits can extend to discourse production, which has emerged as a promising task to evaluate language processing and recovery in aphasia. Here, after characterizing the lesion and white matter integrity predictors for discourse production before treatment, we asked whether brain integrity at baseline is predictive of treatment generalization to discourse. In a large sample of participants with chronic aphasia (

Indexed as

chronic aphasiadiscoursegeneralizationhippocampuslesion-symptom mappingtreatment

Identifiers

PMID41445840
PMCPMC12727049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.