Evidence map›Paper›PMID 41445794›Full record

ArticleFrontiers in oncology2025

Citywide community-based colorectal cancer screening in urban Shanghai: age and sex variations in risk mitigation from 1973 to 2020.

Mengyin Wu, Yangming Gong, Chunxiao Wu, Peng Peng, Lei Chen, Qi Li, Liang Shi, Yongmei Xiang, Jianming Dou, Yi Pang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengyin Wu *Division of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yangming Gong *Division of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Chunxiao WuDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Peng PengDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Lei ChenDivision of Public Health Informatics, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Qi LiDivision of Public Health Informatics, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Liang ShiDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yongmei XiangDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Jianming DouDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yi PangDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Xiaocong ZhangDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Kai GuDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Yan ShiDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To evaluate the impact of Shanghai's community colorectal cancer (CRC) screening program on CRC epidemiology and risk reduction. Materials and methods: Data from the Shanghai Cancer Registry (1973-2020) were analyzed. Launched in 2013, the program targets residents aged 50-74, offering free risk assessment (questionnaire and fecal tests). High-risk individuals are advised for colonoscopy (non-mandatory). Interrupted time-series analysis assessed age-standardized incidence and mortality trends. Results: Over 3 million individuals were screened, with 18.7% high-risk and 27-32% undergoing colonoscopy. Screening did not significantly reduce CRC incidence but led to a mortality decline (annual percent change [APC]: 1.07% to -3.16%, Conclusion: The program significantly reduced CRC mortality, particularly in females and the elderly, though incidence trends varied by age. Despite a significant reduction in mortality, the observed stability in overall CRC incidence is an expected finding in the initial years of a screening program. This pattern is largely due to increased detection of prevalent pre-existing cases during the first screening round, which may temporarily offset the decline in incident cases.

Indexed as

colorectal cancerepidemiological studyinterrupted time-series analysisscreeningtrend

Identifiers

PMID41445794
PMCPMC12722893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.