Evidence map›Paper›PMID 41445778›Full record

ReviewEuropean heart journal. Imaging methods and practice2025

Right heart flow hemodynamic assessment using 4D flow CMR: a systematic review.

Alexander Gall, Rui Li, Gareth Matthews, Karl-Philipp Rommel, João L Cavalcante, Pankaj Garg

Abstract readReview
In one paragraph

Review in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander GallNorwich Medical School, University of East Anglia, Norwich, UK.ORCID https://orcid.org/0000-0001-7700-3400
Rui LiNorwich Medical School, University of East Anglia, Norwich, UK.
Gareth MatthewsNorwich Medical School, University of East Anglia, Norwich, UK.ORCID https://orcid.org/0000-0001-8353-4806
Karl-Philipp RommelDepartment of Cardiology, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
João L CavalcanteImaging Department, Allina Health Minneapolis Heart Institute, Minneapolis, MN, USA.
Pankaj GargNorwich Medical School, University of East Anglia, Norwich, UK.ORCID https://orcid.org/0000-0002-5483-169X

Funding

Wellcome Trust
6 · The paper itself

Abstract

Right heart dysfunction increases morbidity and mortality in cardiovascular diseases. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) imaging evaluates detailed right heart physiology, including vorticity, flow dynamics, kinetic energy (KE) and energy loss (EL). This systematic review synthesized literature using 4D flow CMR to assess right atrial (RA) and right ventricular (RV) hemodynamics in health and disease. A systematic search of the Scopus database (up to March 2025) identified observational studies investigating 4D flow CMR of right heart function in adults. Data on RA flow dynamics, RV flow components, KE, EL, and hemodynamic parameters were narratively synthesized. Quality assessment used the AXIS tool From 240 identified articles, 17 studies (894 participants) met eligibility criteria, including healthy individuals and patients with pulmonary hypertension (PH). RA flow dynamics, described in five studies, were characterized by a dominant vortex in health, interrupted with disease. RV flow components consistently showed a decline in direct flow and increased residual volume with disease. Atrial and ventricular KE assessments revealed age, sex, and disease-specific alterations, with rotational flow appearing to conserve right atrial KE. Increased EL was noted in PH. 4D flow CMR is a powerful tool for assessing novel right heart hemodynamic parameters. Quantifying flow patterns, components, and energetics provides a comprehensive overview of right heart function, promising to improve the diagnosis, management, and prognostic stratification of right heart diseases.

Indexed as

cardiovascular magnetic resonance imagingright atriumright ventricle

Identifiers

PMID41445778
PMCPMC12723137

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.