Evidence map›Paper›PMID 41445750›Full record

ArticleFrontiers in immunology2025

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1.

Zhongwen Hu, Hossam Abdelrahman, Abdelrahman Elwy, Fei Kuang, Swati Dhiman, Shafaqat Ali, Marcel Marson, Lisa Holnsteiner, Thamer A Hamdan, Justa Friebus-Kardash and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhongwen Hu *Institute of Immunology, University of Duisburg-Essen, Essen, Germany.
Hossam Abdelrahman *Institute of Immunology, University of Duisburg-Essen, Essen, Germany.
Abdelrahman ElwyInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Fei KuangInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Swati DhimanInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Shafaqat AliInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Marcel MarsonInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Lisa HolnsteinerInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Thamer A HamdanInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Justa Friebus-KardashInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Elisa WiebeckInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Wiebke HansenInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Stefanie ScheuInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Erich GulbinsInstitute of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
Philipp Alexander LangDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Karl Sebastian LangInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.
Judith LangInstitute of Immunology, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides its robust antiviral activity, type I interferon (IFN-I) also exerts immunomodulatory effects and can even drive pathology during chronic viral infections. Mechanisms that regulate IFN-I induction during virus infection, thus strongly affecting the outcome of disease, remain to be defined. Here, using the lymphocytic choriomeningitis virus (LCMV) Docile strain, we identified acid ceramidase (aCDase,

Indexed as

Acid CeramidaseB7-H1 AntigenCD8-Positive T-LymphocytesInterferon Type ILymphocytic ChoriomeningitisLymphocytic choriomeningitis virusAnimalsCeramidesDendritic CellsMiceMice, Inbred C57BLMice, KnockoutT-Cell ExhaustionUp-RegulationAcid CeramidaseAsah1 protein, mouseB7-H1 AntigenCd274 protein, mouseCeramidesInterferon Type Iacid ceramidase (aCDase)ceramidechronic infectionLCMV Docileplasmacytoid dendritic cellprogrammed death ligand 1 (PD-L1)T cell exhaustiontype I interferon

Identifiers

PMID41445750
PMCPMC12722844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.