ArticleFrontiers in immunology2025
Modulation of
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The host response to SARS-CoV-2 depends on multiple factors including age, gender, underlying diseases and genetic background. Viral sensing and activation of the interferon signaling pathway in the early antiviral response could affect disease outcome. This study evaluated gene expression of Toll-like receptor 7 ( Methods: Demographic and clinical variables were obtained from 157 COVID-19 patients. Peripheral blood mononuclear cells were used for genotyping and gene expression determination, and plasma for viremia detection, by qPCR and digital PCR, respectively. Gene expression was analyzed using Generalized Linear Mixed Models nested by patient. First, univariate analyses determined which variables were significantly associated with gene expression. Next, multivariate models were built with these variables, following the backward method. Results: Conclusions: Low
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.