ArticlemedRxiv : the preprint server for health sciences2025
Comparison of Masimo Rad-67 SpHb non-invasive hemoglobin monitoring device with complete blood count measurement for use in pregnancy: An observational multi-site cohort study.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Validation of Non-Invasive Hemoglobin Measurement and Its Utility for Anemia Screening in Pregnancy: A Cross-Sectional Diagnostic Accuracy Study.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
21 authors.
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Abstract
Background: Anemia remains a major health concern, particularly during pregnancy. However, blood draws, laboratory capacity, processing time, and equipment cost required for hemoglobin testing to diagnose anemia can be prohibitive. The Total Hemoglobin SpHb Rad-67 Pulse CO-Oximeter offers a non-invasive, portable, and affordable point-of-care alternative. We aimed to validate SpHb against complete blood count (CBC) in a pregnant and postpartum population. Methods: This was a substudy of the Pregnancy Risk, Infant Surveillance, and Measurement Alliance (PRISMA) Maternal and Newborn Health Study. A total of 2,700 participants in Zambia, Kenya, and Pakistan provided hemoglobin measurements both by CBC and the Rad-67 Masimo SpHb device at four visits during pregnancy and at six-weeks postpartum. We assessed agreement between SpHb and CBC and used mixed models to identify factors that explained or influenced differences between the two methods. Results: We found the mean hemoglobin measurement by SpHb (12.8±1.6 g/dL) was higher than by CBC (11.0±1.6 g/dL). However, this overall positive bias masked systematic misclassification at the extremes: SpHb overestimated values among women with very low hemoglobin (Mean Difference (MD) = -3.95; 95%CI -4.28, -3.62) and underestimated values at very high hemoglobin levels (MD = 2.44; 95%CI 2.14, 2.74), even after adjustment. Using CBC, 48% of observations were classified as anemic (<11 g/dL), compared to 9% by SpHb; conversely, just 7% of CBC readings fell within 13-15 g/dL, compared to 38% by SpHb. Agreement metrics consistently showed poor concordance between the two methods. Conclusions: SpHb systematically overestimated hemoglobin on average and showed poor agreement with CBC, particularly at clinically relevant extremes. Until greater accuracy of SpHb is demonstrated in this population, hemoglobin testing with laboratory-based methods is recommended to inform clinical decision-making in pregnancy.
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