Evidence map›Paper›PMID 41445628›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genetic Architecture of Alcohol Use Disorder in Nepal.

Justin D Tubbs, Yixuan He, Kristin Tsuo, Mary T Yohannes, Younga H Lee, Emily M Madsen, Dirgha J Ghimire, Sabrina Hermosilla, Tian Ge, Alicia R Martin and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Justin D TubbsDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA.ORCID 0000-0002-6671-6816
Yixuan HeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Kristin TsuoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Mary T YohannesStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Younga H LeeDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA.
Emily M MadsenPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston Massachusetts, USA.
Dirgha J GhimirePopulation Studies Center, Institute for Social Research, University of Michigan, Ann Arbor Michigan, USA.
Sabrina HermosillaPopulation Studies Center, Institute for Social Research, University of Michigan, Ann Arbor Michigan, USA.
Tian GeDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA.
Alicia R MartinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Karmel W ChoiDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA.
Jordan W SmollerDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA.
William G AxinnPopulation Studies Center, Institute for Social Research, University of Michigan, Ann Arbor Michigan, USA.

Funding

Scientific/Technical CoreP2CHD041028 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brady T West · 2017 to 2026
$6.5M
Understanding the Connections among Genes, Environment, Family Processes, and Mental HealthR01MH110872 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AXINN, WILLIAM G., SMOLLER, JORDAN W · 2017 to 2020
$3.5M
Partners Healthcare Training Program in Precision and Genomic MedicineT32HG010464 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDI L REHM, JORDAN W SMOLLER · 2019 to 2026
$3.1M
Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression RiskK08MH127413 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, KARMEL · 2021 to 2025
$987k
Integrating genomics and EHR to accelerate precision psychiatryK01MH141330 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Justin Tubbs · 2025 to 2026
$365k
NHGRI NIH HHS T32 HG010464NICHD NIH HHS P2C HD041028NIMH NIH HHS K01 MH141330NIMH NIH HHS K08 MH127413NIMH NIH HHS R01 MH110872
6 · The paper itself

Abstract

Alcohol use disorder (AUD) is a serious psychiatric condition associated with negative health and psychosocial consequences, comprising core symptoms of compulsive heavy drinking that impairs daily functioning. Genetic factors play a major role in AUD etiology, estimated to explain around 50% of variation in risk. Despite being a major global public health concern, the vast majority of genetic and epidemiological studies of AUD have been restricted to samples of European ancestry living in high-income countries. Using data from the Chitwan Valley Family Study, we perform the first comprehensive genetic study of AUD in a unique Nepalese sample of 10,032 individuals. We find significantly lower estimates of narrow-sense heritability (0.21, SE=0.06) compared to prior estimates from European and North American contexts. We also identified a novel genome-wide significant locus on chromosome 4 (lead SNP rs4323051,

Identifiers

PMID41445628
PMCPMC12723783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.