ArticlemedRxiv : the preprint server for health sciences2025
A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Midbrain length by the one-line method predicts motor outcome after deep brain stimulation in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
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Authors and funding
60 authors.
Barbara HollunderCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0104-6927
Garance M MeyerCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3350-6070
Ningfei LiDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-3315-3591
Pablo ReinhardtDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ilkem Aysu SahinDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0009-0005-9951-374X
Nanditha RajamaniCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2511-9839
Julianna PijarCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cristina NombelaBiological and Health Psychology, School of Psychology, Universidad Autónoma de Madrid, Spain.ORCID 0000-0002-9806-2351
Philip MosleyClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0003-1721-3419
Nicola AcevedoCentre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia.ORCID 0000-0003-3059-3620
Kara A JohnsonNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-6556-8957
Nicole ProvenzaDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6952-5417
Harith AkramDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-2899-628X
Benjamin M BorronDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9041-8907
Tina ChouDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jürgen GermannDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-0995-8226
Juan Pablo Castaño MontoyaDepartment of Neurosurgery, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos, Universidad Complutense de Madrid, Madrid, Spain.
Bryan StrangeLaboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid, Spain.ORCID 0000-0001-6476-4091
Juan A BarciaDepartment of Neurosurgery, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos, Universidad Complutense de Madrid, Madrid, Spain.
Himanshu TyagiDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
David J CastleUniversity of Tasmania and Centre for Mental Health Service Innovation, Tasmania, Australia.ORCID 0000-0002-3075-1580
Susan RossellCentre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia.ORCID 0000-0002-7415-8252
Peter BosanacSt.Vincent's Hospital Melbourne, Melbourne, Australia.
Carsten FinkeDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-7665-1171
Andrea A KühnDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Domenico ServelloNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Lombardia, Italy.
Alberto R BonaNeurosurgical Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Lombardia, Italy.
Mauro PortaTourette's Syndrome and Movement Disorders Center, IRCCS Istituto Ortopedico Galeazzi, Milan, Lombardia, Italy.
Alon Y MogilnerCenter for Neuromodulation, Departments of Neurology and Neurosurgery, New York University Medical Center, New York, New York, USA.ORCID 0000-0003-1493-0463
Michael H PourfarCenter for Neuromodulation, Departments of Neurology and Neurosurgery, New York University Medical Center, New York, New York, USA.
Jill L OstremDepartment of Neurology, University of California San Francisco, San Francisco, California, USA.
Jens KuhnDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-5274-7929
Stephan ChabardesUniversité Grenoble Alpes, Grenoble, France.ORCID 0000-0002-7930-1476
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8770-8965
Wayne K GoodmanDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Andrew H SmithNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ki Sueng ChoiNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6446-0677
Brian H KopellNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Helen S MaybergNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Martijn FigeeNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3679-284X
Thomas FoltynieDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0003-0752-1813
Patricia LimousinDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-5668-5545
Linda AckermansDepartment of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Joost J A de JongDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Netherlands.ORCID 0000-0003-4469-0763
Albert F G LeentjensDepartment of Psychiatry, Maastricht University Medical Center, Maastricht, Netherlands.
Christopher R ButsonNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-2319-1263
Michael S OkunNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-6247-9358
R Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
G Rees CosgroveCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shan H SiddiqiCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0967-9289
Andres M LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Ludvic ZrinzoDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-6013-4946
Eileen JoyceDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0003-0469-2844
Mircea PolosanUniversité Grenoble Alpes, Grenoble, France.
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Juan Carlos BaldermannDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-2620-7387
Michael D FoxCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andreas HornCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0695-6025
Funding
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5MUsing human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9MToward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9MUsing Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4MNIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892NINDS NIH HHS UM1 NS132358
Abstract
Obsessive-compulsive disorder (OCD) manifests with diverse symptom constellations that likely arise from dysfunction in partially distinct neural circuits. Deep brain stimulation (DBS), paired with highresolution connectomics, offers a unique window into these pathways in humans. Here, we analyzed clinical outcomes and stimulation sites from 77 treatment-refractory patients with OCD and 39 with Tourette's syndrome (TS) exhibiting comorbid obsessive-compulsive behaviors (244 electrodes across 15 cohorts and eight targets). Engagement of the previously defined
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.