ArticleFrontiers in cell and developmental biology2025
Maternal provisioning and zygotic activation: transcriptomic dynamics of early atlantic halibut (
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: In Atlantic halibut ( Methods: We performed stage-resolved RNA sequencing of Atlantic halibut embryos spanning unfertilized egg (UF), cleavage (8C, 16C), blastula (BL), 25% epiboly (25 EB), and blastopore closure (50 degree-days, 50 dd). Differential expression analysis (DESeq2 with LFC shrinkage), Gene Ontology (GO) overrepresentation (PANTHER, REVIGO), and curated axis-patterning gene sets from zebrafish orthologs were used to map transcriptional dynamics. Results: Minimal transcriptional change occurred during cleavage (UF-16C), dominated by maternal transcripts. A pronounced transcriptional shift emerged at MBT (16C→BL), marked by upregulation of canonical developmental pathways (Wnt, BMP, Notch) and axis-specification genes (e.g., Discussion: Our results demonstrate that the decisive transcriptional programs underlying axis formation and organogenesis are activated from MBT onward. These findings imply that comparisons limited to unfertilized or early cleavage stages cannot capture the biology determining embryo viability. Stage-resolved analyses encompassing MBT and gastrulation are therefore essential for identifying transcriptomic markers of egg and larval quality in halibut.
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