ReviewCancer cell international2025
MicroRNAs as the critical regulators of ubiquitin-proteasome system through F-box protein targeting during tumor progression.
Review in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ubiquitin-proteasome system (UPS) as a crucial mechanism for protein degradation is involved in regulation of cellular processes. Dysregulation of UPS can be associated with tumor progression by modulation of tumor suppressors and oncogenes. F-box proteins (FBPs) play a significant role in the ubiquitin-proteasome pathway (UPP) by targeting specific protein sequences and engaging in post-translational modifications, thus affecting various pathophysiological processes. MiRNAs regulate FBP functions, and their deregulation has been observed in numerous cancers. In the present review, we discussed the role of miRNAs in tumor progression by regulation of FBPs. FBXW7 is the main F-box protein that can be modulated by the miRNAs in tumor cells. It has been shown that miRNAs had mainly oncogenic functions in tumor cells by FBPs targeting. MiRNA/FBP axis can be introduced as a reliable diagnostic and therapeutic option in cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.