Evidence map›Paper›PMID 41444873›Full record

ArticleBMC microbiology2025

Immunogenicity of a bivalent recombinant adenovirus expressing VP1 proteins of bovine norovirus and bovine nebovirus in mice and calves.

Taoyun Chen, Jun Chu, Xin Song, Qisheng Yu, Gunan Deng, Jiangyong Zeng, Changqing Yu, Bin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical and Epidemiological Features of Calicivirus Infections in Cattle.Animals : an open access journal from MDPI · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Taoyun Chen *College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Jun Chu *Institute of Animal Science, Tibet Academy of Agricultural and Animal Husbandry Science, Lhasa, 850009, China.
Xin SongCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Qisheng YuCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Gunan DengCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China.
Jiangyong ZengInstitute of Animal Science, Tibet Academy of Agricultural and Animal Husbandry Science, Lhasa, 850009, China. zengjiangyong@126.com.
Changqing YuEngineering Center of Agricultural Biosafety Assessment and Biotechnology, School of Advanced Agricultural Sciences, Yibin Vocational and Technical College, Yibin, 644001, China. ycq_1926@126.com.
Bin ZhangCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, China. binovy@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine norovirus (BNoV) and bovine nebovirus (BNeV) are emerging pathogens responsible for severe diarrhea in calves worldwide. In this study, we constructed a bivalent recombinant adenovirus vector vaccine, designated rAd5-BNoV + BNeV_VP1 encoding the genes for BNoV-VP1 and BNeV-VP1 based on replication-deficient human adenovirus type 5 (rAd5), and evaluated its immunogenicity in mice and calves. Serum antibody responses were assessed by enzyme-linked immunosorbent assay (ELISA) and serum blocking titer 50 (BT50). Results demonstrated that mice immunized with rAd5-BNoV + BNeV_VP1 produced significant VP1-specific IgG titers as early as two weeks post-vaccination. BNoV-VP1-specific IgG antibody titers peaked at 1:10

Indexed as

AdenoviridaeCaliciviridae InfectionsCapsid ProteinsCattle DiseasesNorovirusViral VaccinesAnimalsAntibodies, ViralCattleFemaleGenetic VectorsImmunoglobulin GMiceMice, Inbred BALB CVaccines, SyntheticAntibodies, ViralCapsid ProteinsImmunoglobulin GVaccines, SyntheticViral VaccinesBovine nebovirusBovine norovirusImmune effectsReplication-deficient human type 5 adenovirus vectorVP1 protein

Identifiers

PMID41444873
PMCPMC12729173

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.