Trial reportAging clinical and experimental research2025
Effectiveness of a multidomain lifestyle counseling intervention on intrinsic capacity in older women: a randomized clinical trial.
Trial report in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundIntrinsic capacity (IC), the composite of physical and mental capacities, is crucial for health and well-being in older adults. With aging populations experiencing IC decline, effective interventions are needed to promote healthy aging. This study evaluated the effectiveness of a structured lifestyle counseling program on IC in older women.
methodsIn this 8-week cluster randomized controlled trial, 240 women aged ≥ 60 were equally allocated to intervention or control groups. The intervention group participated in an 8-session (30-45 min/session) counseling program delivered in small groups (10 participants each), focusing on five IC domains: nutrition (vitality), physical exercise (locomotion), psychological well-being (happiness/depression management), cognitive stimulation, and sensory health. Sessions included education, goal-setting, and interactive discussions. The control group received no intervention during the study period but obtained educational materials post-trial. IC domains were assessed at baseline and 1-week post-intervention using validated tools: SPPB and TUG (locomotion), Mini-Cog (cognition), GDS (Geriatric Depression Scale) (psychological), MNA (Mini Nutritional Assessment) (vitality), and self-reported sensory measures.
resultsThe intervention group showed significantly greater improvement in overall IC compared to controls (adjusted mean difference [aMD] = 2.07, 95%CI: 1.69, 2.44). Domain-specific improvements included locomotion (aMD = 0.92, 95%CI: 0.68, 1.16), vitality (aMD =1.01 , 95%CI: 0.67, 1.33), cognition (aMD = 0.80, 95%CI: 0.52, 1.09), psychological (aMD = 2.28, 95%CI:1.37, 3.19), and sensory (aMD = 0.29, 95%CI:0.13, 0.44).
conclusionAn 8-week lifestyle counseling intervention significantly improved intrinsic capacity and its domains in older women. These findings support the implementation of targeted, multidomain interventions to promote healthy aging, though longer-term studies are needed to assess sustained benefits.
trial registrationDate of Registration: 26 June 2023. Date of Initial Participant Enrollment: 6 July 2023, Iranian Registry of Clinical Trials identifier: IRCT20230328057780N1, URL: https://irct.behdasht.gov.ir/trial/69321 .
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