Evidence map›Paper›PMID 41444677›Full record

ArticleJournal of medical case reports2025

Synchronous malignant tumors of the larynx with various histogenesis: leiomyosarcoma and squamous cell carcinoma-A case report.

Olga V Cheremisina, Sergey V Vtorushin, Marina V Vusik, Denis E Kulbakin, Sergei S Naumov, Nadezhda V Krakhmal

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Olga V CheremisinaCancer Research Institute-Branch of Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Street, 634009, Tomsk, Russia.
Sergey V VtorushinCancer Research Institute-Branch of Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Street, 634009, Tomsk, Russia.
Marina V VusikCancer Research Institute-Branch of Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Street, 634009, Tomsk, Russia.
Denis E KulbakinCancer Research Institute-Branch of Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Street, 634009, Tomsk, Russia.
Sergei S NaumovSiberian State Medical University, 2 Moskovsky tract, 634050, Tomsk, Russia. serg.nau2011@gmail.com.
Nadezhda V KrakhmalCancer Research Institute-Branch of Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Street, 634009, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSquamous cell carcinoma accounts for up to 95% of malignant laryngeal tumors, whereas leiomyosarcoma is exceptionally rare, with fewer than 50 cases reported worldwide. The synchronous occurrence of two histogenetically distinct malignancies in the larynx is extremely uncommon and represents a diagnostic and therapeutic challenge. CASE PRESENTATION: We describe a 66-year-old Caucasian male with synchronous laryngeal tumors: a well-differentiated squamous cell carcinoma of the right vocal fold and a high-grade leiomyosarcoma of the subglottic region. Diagnosis was established using endoscopy, histopathology, and immunohistochemistry. The patient underwent total laryngectomy with permanent tracheostomy followed by adjuvant radiotherapy. At follow-up, no recurrence or progression was detected.

conclusionThis case illustrates the rare coexistence of epithelial and mesenchymal malignancies in the larynx and emphasizes the importance of multimodal diagnostic evaluation to guide optimal surgical management.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsLeiomyosarcomaNeoplasms, Multiple PrimaryAgedHumansLaryngectomyMaleRadiotherapy, AdjuvantTracheostomyVocal CordsCase reportLeiomyosarcomaMorphologySquamous cell carcinomaSynchronous malignant tumors of the larynx

Identifiers

PMID41444677
PMCPMC12729008

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