ArticleJournal of ovarian research2025
Alkaloids isolated from Scutellaria Barbata D. Don trigger apoptosis and inhibit migration by modulating the p38-p53 pathway in ovarian cancer.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Modulation of Antitumor Immunity and the Tumor Microenvironment byInternational journal of molecular sciences · 2026Article
- Targeting PAI-1 with TM5441 Mitigates Chronic Social Stress-Induced Anxiety-Like Behavior and Stress-Induced Increases in Ethanol Intake and Preference.Neurochemical research · 2026Article
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Abstract
backgroundOvarian cancer is a widely prevalent gynecological malignancy associated with significant morbidity and mortality. Scutellaria barbata D. Don (SB), a traditional Chinese medicine, has been reported to have diverse biological effects, including anti-ovarian cancer effects. However, the specific effects and underlying mechanism of the alkaloid fraction, the active fraction isolated from SB, in ovarian cancer remain unclear. This study aimed to explore the anti-tumor effects and underlying mechanisms of the alkaloid fraction of Scutellaria barbata D. Don (SBA) in ovarian cancer.
methodsSBA was extracted by alcohol solvent extraction, and its chemical composition was analyzed using chromogenic reaction and high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF-MS). The effects of SBA on the proliferation, migration and apoptosis of human ovarian cancer cells (SKOV3) were detected by CCK-8 assay, clone formation assay, scratch assay, transwell assay, flow cytometry, Hoechst 33,342 staining and Western blot. SKOV3 xenograft nude mouse model was established to further investigate the in vivo effects of SBA. Serum and tissue samples were collected for molecular-biological indicators, and pathological changes were evaluated by hematoxylin-eosin, immunohistochemistry, and Western blot.
resultsA total of 38 nitrogen-containing compounds were detected in SBA. SBA inhibited the proliferation and migration of SKOV3 cells in a dose-dependent manner, in addition to inducing significant cell apoptosis. In the SKOV3 xenograft model, SBA attenuated ovarian cancer tumor growth with no significant organ toxicity. The anti-tumor effects of SBA were associated with downregulation of Bcl-2, N-cadherin, MMP2, MMP9, and upregulation of Bax, cleaved caspase-3/ caspase-3, cleaved caspase-9, E-cadherin, P-p38/ p38, and P-p53/ p53 both in vitro and in vivo. Additionally, SBA exhibited synergy with cisplatin (DDP) and alleviated cisplatin-induced renal damage.
conclusionSBA suppresses ovarian cancer by triggering apoptosis and inhibiting cell migration via the p38-p53 pathway. Combining SBA with DDP reduces drug toxicity and potentiates the anti-tumor effects. Therefore, SBA is a promising candidate for treating ovarian cancer, and mitigating the toxic side effects of DDP in ovarian cancer.
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