ReviewCell communication and signaling : CCS2025
Cancer-associated fibroblasts: central players in cancer hallmarks and therapeutic resistance.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Review
- Developing a melanoma-skin-on-a-chip integrated with vasculature using an edgeless skin reconstruction approach.Research square · 2026Article
- Polymeric Nano Drug Delivery Systems for Overcoming Tumor Microenvironment-Mediated Drug Resistance.Pharmaceutics · 2026Review
- Beyond Structure: The Dynamic Role of the Extracellular Matrix Components in Immune Evasion.Cancer communications (London, England) · 2026Review
- T-cell engagers in cancer immunotherapy: mechanisms, challenges, and future perspectives.Frontiers in immunology · 2026Review
- Multidimensional tumor heterogeneity and its role in therapeutic resistance.Frontiers in immunology · 2026Review
- Cancer-Associated Fibroblast-Targeted Nanomedicine in Solid Tumor Therapy: From Mechanisms of Therapeutic Resistance to Precision Stromal Modulation.International journal of nanomedicine · 2026Review
- A Spatially Constrained Fibroblast-Myeloid Program Associates With Immune Exclusion and Poor Prognosis in Lung Adenocarcinoma.Human mutation · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The tumour microenvironment (TME) is now recognized as pivotal to cancer progression and treatment outcomes, alongside cancer cell-intrinsic factors. Among TME constitute, cancer-associated fibroblasts (CAFs) are abundant and actively shape tumour biology. They are heterogenous population arising from multiple origins, and engage in dynamic crosstalk with cancer cells and immune infiltrates to promote virtually all the hallmarks of cancer. By influencing and reinforcement of cancer hallmark traits, CAFs create a pro-tumorigenic niche that also protects cancer cells from therapy, in this way, conferring resistance to conventional therapy. Consequently, CAFs have emerged as central players linking cancer hallmarks to therapeutic resistance. This review discusses the origins and phenotypic diversity of CAFs, the mechanisms of their communication with tumour and immune cells, and how these interactions enforce hallmark capabilities of cancer that underlie treatment resistance. We also highlight preclinical and clinical evidence for CAF-driven drug resistance and examine current strategies to target CAFs or their effects. A deeper understanding of CAF heterogeneity and function could pave the way for novel combination therapies that dismantle the tumour-CAF alliance and improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.