ArticleCancer cell international2025
Quantitative HER2 profiling on circulating tumor cells using an EpCAM-independent platform in metastatic breast cancer.
Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Liquid Biopsy Revolutionizes the Precise Management of Tumors Across the Entire Course: Current Situation and Future Prospects].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- A workflow for assessing antibody-drug conjugate target expression on circulating tumour cells from triple-negative breast cancer and epithelial ovarian cancer patients.The journal of liquid biopsy · 2026Article
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17 authors.
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Abstract
backgroundAccurate human epidermal growth factor 2 (HER2) assessment is critical for guiding breast cancer (BC) treatment. Circulating tumor cells (CTCs), which detach from the primary or secondary tumors and circulate through the bloodstream, can colonize distant sites to form metastases. Previous studies have demonstrated the clinical validity of CTCs as prognostic biomarkers in metastatic breast cancer (mBC). Liquid biopsy testing offers a non-invasive alternative for real-time evaluation of HER2 expression on CTCs, overcoming limitations of repeated histological sampling.
methodsThis study employed a pipeline combining EpCAM-independent enrichment with Parsortix
resultsThe two methods had a strong positive correlation in CTC counts, with the label-free workflow showing a higher CTC detection (100% versus 77% samples with ≥ 1 CTC). Median total CTC counts per 7.5 mL blood were 16.5 (range 3-65) for Parsortix
conclusionThese results support the clinical utility of HER2 assessment on CTCs with both workflows and highlight the potential diagnostic value of label-free CTC enrichment combined with HER2 quantification. Further studies in larger cohorts should be conducted to validate our findings and investigate the clinical relevance of HER2-positive CTCs detected with the developed pipeline, particularly in the context of anti-HER2 therapies.
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