Evidence map›Paper›PMID 41444562›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2025

Comments on "The effects of norepinephrine in shockable cardiac arrest, a scoping review".

Samantha Camp, Caitlin Williams, Ali Pourmand, Quincy K Tran

Abstract readLetterComment
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reply to: comments on "The effects of norepinephrine in shockable cardiac arrest, a scoping review".Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Samantha CampUniversity of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA. samantha.camp@som.umaryland.edu.
Caitlin WilliamsDepartment of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Ali PourmandDepartment of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Quincy K TranDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Norepinephrine in shockable cardiac arrest is a controversial topic. The review from Bouman et al. relies heavily on historical animal studies with limited human data, thus, their conclusion may not be clinically applicable. Current available data demonstrates significant heterogeneity, such as norepinephrine dosing and administration routes. Furthermore, a recent meta-analysis suggests no clear survival or neurologic benefit of norepinephrine over epinephrine. The assertions about neurologic outcomes, which were based on animal hemodynamics, were not supported by sufficient human evidence in the recent meta-analysis. Overall, the authors' conclusions may be too much of an overreach, due to given the variability and limitations of the included studies, warranting cautious interpretation.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestNorepinephrineVasoconstrictor AgentsAnimalsHumansScoping Reviews as TopicNorepinephrineVasoconstrictor Agents

Identifiers

PMID41444562
PMCPMC12729065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.