Evidence map›Paper›PMID 41444479›Full record

ArticleNature communications2025

Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice.

Fabien Ducrocq, Lianne Delwel, Nick Papavoine, Eileen Brouwer, Karlijn L Kooij, Inge G Wolterink-Donselaar, Lisa Drost, Jaimie Hak, Melissa Veendijk, Mieneke C M Luijendijk and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fabien DucrocqDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. fabien.ducrocq@inrae.fr.ORCID http://orcid.org/0009-0008-8041-6212
Lianne DelwelDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Nick PapavoineDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0009-0002-6872-354X
Eileen BrouwerDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Karlijn L KooijDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Inge G Wolterink-DonselaarDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Lisa DrostDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Jaimie HakDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Melissa VeendijkDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Mieneke C M LuijendijkDepartment of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0009-0007-3035-452X
Frank J Meye *Department of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. F.J.Meye-2@umcutrecht.nl.ORCID http://orcid.org/0000-0002-4730-2474
Roger A H Adan *Department of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. r.a.h.adan@umcutrecht.nl.ORCID http://orcid.org/0000-0001-8994-0661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) has the highest mortality among psychiatric disorders, with hyperactivity being one of the most persistent and deleterious symptoms. Increased dopamine transmission is linked to AN and hyperactivity, though the underlying mechanisms remain unclear. Local GABAergic neurons powerfully regulate the dopamine system but their involvement in AN is unknown. Using the activity-based anorexia (ABA) mouse model, we found that GABAergic transmission onto ventral tegmental area dopamine (VTA

Indexed as

AnorexiaAnorexia NervosaGABAergic NeuronsHyperkinesisVentral Tegmental AreaAnimalsDisease Models, AnimalDopamineDopaminergic NeuronsFemalegamma-Aminobutyric AcidMiceMice, Inbred C57BLDopaminegamma-Aminobutyric Acid

Identifiers

PMID41444479
PMCPMC12855961

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.