ArticleNature communications2025
Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anorexia nervosa (AN) has the highest mortality among psychiatric disorders, with hyperactivity being one of the most persistent and deleterious symptoms. Increased dopamine transmission is linked to AN and hyperactivity, though the underlying mechanisms remain unclear. Local GABAergic neurons powerfully regulate the dopamine system but their involvement in AN is unknown. Using the activity-based anorexia (ABA) mouse model, we found that GABAergic transmission onto ventral tegmental area dopamine (VTA
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