Evidence map›Paper›PMID 41444468›Full record

ArticleJournal of natural medicines2026

Pachyphylinin A-B: two novel seco-apotirucallane triterpenoids with cytotoxic activities from the stem bark of Aglaia pachyphylla.

Wahyu Safriansyah, Erina Hilmayanti, Rustaman, Kindi Farabi, Mohamad Azlan Nafiah, Mohamad Nurul Azmi, Sofa Fajriah, Kazuya Kabayama, Atsushi Shimoyama, Yoshiyuki Manabe and 4 more

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wahyu SafriansyahEijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jalan Raya Bogor Km. 46, Cibinong, Bogor, 16911, Indonesia.
Erina HilmayantiDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan.
RustamanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Kindi FarabiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Mohamad Azlan NafiahDepartment of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, Tanjung Malim, 35900, Perak, Malaysia.
Mohamad Nurul AzmiSchool of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang, 11800, Malaysia.
Sofa FajriahResearch Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK, Serpong, Tangerang Selatan, 15314, Indonesia.
Kazuya KabayamaDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan.
Atsushi ShimoyamaDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan.
Yoshiyuki ManabeDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan.
Koichi FukaseDepartment of Chemistry, Graduate School of Science, Osaka University, Toyonaka, 560-0043, Japan.
Hadi KuncoroFaculty of Pharmacy, Mulawarman University, Samarinda, 75119, Indonesia.
Unang SupratmanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Desi HarnetiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia. desi.harneti@unpad.ac.id.

Funding

Kementerian Riset, Teknologi dan Pendidikan Tinggi (250.13/E4.4/KU/2024)Kementerian Riset, Teknologi dan Pendidikan Tinggi (3166/UN6.3.1/PT.00/2024)Universitas Padjadjaran (1433/UN6.3.1/PT.00/2024)
6 · The paper itself

Abstract

New seco-apotirucallane triterpenoids, pachyphylinin A (1) and B (2), were isolated from the stem bark of Aglaia pachyphylla alongside nine triterpenoid compounds (3-11). The structures were elucidated and identified through various spectroscopic analyses, including 1D and 2D NMR, HRTOF-MS, FTIR, as well as ECD, complemented by computational calculation using TD-DFT. In the process, pachyphylinin A (1) and B (2) were tested for cytotoxic activity against the breast cancer cell line (MCF-7). The results showed cytotoxic activities against MCF-7 with IC

Indexed as

AglaiaAntineoplastic Agents, PhytogenicPlant BarkPlant ExtractsTriterpenesHumansMCF-7 CellsMolecular StructurePlant StemsAntineoplastic Agents, PhytogenicPlant ExtractsTriterpenesAglaia pachypyllaCytotoxic activityMCF-7 cell lineSeco-apotirucallane triterpenoids

Identifiers

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.