ArticlePediatric research2026
Post-stem cell transplantation pediatric gastrointestinal graft-versus-host disease: nomogram analysis of clinical and endoscopic features.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal graft-versus-host disease (GI-GVHD) is diagnosed via histological examination of endoscopic mucosal biopsy specimens; however, the optimal endoscopic diagnostic strategy remains unclear. This study aimed to identify key clinical symptoms, gastrointestinal sites, and endoscopic approaches for diagnosing pediatric GI-GVHD.
methodsA retrospective analysis of post-bone marrow stem cell transplant patients with gastrointestinal symptoms at Shanghai Children's Medical Center (2018-2023) was conducted. A nomogram prediction model was developed using univariate and multivariate logistic regression analyses based on clinical, endoscopic, and histopathological characteristics.
resultsAmong 63 patients (29 GI-GVHD, 34 non-GI-GVHD), GI-GVHD was associated with skin rejection (P = 0.002), diarrhea (P = 0.07), and bloody stools (P = 0.009). C-reactive protein (CRP) > 30 mg/L and mucosal ulcers were more common in the non-GI-GVHD group than the GI-GVHD group (P = 0.016, P = 0.029). Independent GI-GVHD indicators included skin rejection (P = 0.035), apoptotic corpuscles (P = 0.030), mucosal edema (P = 0.007), and tortoise shell-like mucosa (P = 0.020). Transverse colonic mucosal edema (76.2%) and tortoise shell-like mucosa (74.6%) demonstrated the highest diagnostic accuracy in the nomogram.
conclusionsGastroscopy combined with colonoscopy is recommended for diagnosing GI-GVHD. The key diagnostic indicators include skin rejection, mucosal edema, tortoise shell-like mucosa, and apoptotic corpuscles. Our nomogram aids in GI-GVHD diagnosis. IMPACT: Our study identified key clinical, endoscopic, and histopathological markers for pediatric gastrointestinal graft-versus-host disease (GI-GVHD), emphasizing colonic mucosal edema and tortoise shell-like mucosa as GI-GVHD indicators. Our results underscore the value of combining gastroscopy and colonoscopy while introducing a predictive nomogram for risk assessment. These findings can enhance early and accurate diagnosis, enabling timely, targeted interventions to improve patient outcomes.
Indexed as
Identifiers
41444430What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.