Evidence map›Paper›PMID 41444411›Full record

ArticleNature methods2026

DynamicAtlas: a morphodynamic atlas for Drosophila development.

Matthew F Lefebvre, Vishank Jain-Sharma, Nikolas Claussen, Noah P Mitchell, Marion K Raich, Hannah J Gustafson, Friederike E Streichan, Andreas R Bausch, Sebastian J Streichan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Tissue maps in motion.Nature methods · 2026
    Article
  2. Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Geometric Basis of Epithelial Convergent Extension.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew F Lefebvre *Department of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-9590-4293
Vishank Jain-Sharma *Department of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-0995-1585
Nikolas Claussen *Department of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.
Noah P Mitchell *Department of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-1922-8470
Marion K RaichCenter for Protein Assemblies (CPA) and Lehrstuhl für Biophysik (E27), Physics Department, Technical University of Munich, Garching, Germany.ORCID http://orcid.org/0009-0008-2500-4928
Hannah J GustafsonDepartment of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.
Friederike E StreichanIndependent Researcher, Santa Barbara, CA, USA.
Andreas R BauschCenter for Protein Assemblies (CPA) and Lehrstuhl für Biophysik (E27), Physics Department, Technical University of Munich, Garching, Germany.ORCID http://orcid.org/0000-0002-4608-9544
Sebastian J StreichanDepartment of Physics, University of California Santa Barbara, Santa Barbara, CA, USA. streicha@ucsb.edu.ORCID http://orcid.org/0000-0002-6105-9087

Funding

Physics of Living Matter: From Molecule to Embryo.R35GM138203 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Sebastian J Streichan · 2020 to 2026
$2.7M
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 810104-PoIntNational Science Foundation (NSF) PHY-2047140NIGMS NIH HHS R35 GM138203
6 · The paper itself

Abstract

Living organisms develop their shape through the interplay of gene expression and mechanics. While atlases of static samples characterize cell fates and gene regulation, understanding dynamic shape changes requires live imaging. Here we present DynamicAtlas: a 'morphodynamic atlas' of live and static datasets from 500 Drosophila melanogaster embryos (wild type and 18 mutants), aligned to a common morphological timeline. Surprisingly, characterizing wild-type surface tissue flows reveals distinct 'morphodynamic modules'-time periods in which the global pattern of motion is stationary-corresponding to key developmental stages. Mutant analysis shows stationary flow patterns depend on genes that break spatial symmetry along the dorsal-ventral axis. Temperature perturbations indicate that morphodynamic modules change in response to accumulated tissue deformation, rather than elapsed time. Extending our approach to the embryonic Drosophila midgut, we find modules in covariant measures of the dynamic three-dimensional surface. DynamicAtlas provides a high-resolution framework for studying shape formation across living systems.

Indexed as

Drosophila melanogasterMorphogenesisAnimalsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalImaging, Three-DimensionalMutation

Identifiers

PMID41444411
PMCPMC12791008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.