Evidence map›Paper›PMID 41444404›Full record

ArticleMolecular psychiatry2026

Homeostatic scaling ensures behavioural stability during corticosterone negative feedback.

Neilen Rasiah, Tamás Füzesi, Ewandson L Lameu, Nicolas F Landgraf, David Rosenegger, Spencer P Loewen, Toni-Lee Sterley, Ibukun Akinrinade, Thomas L Kash, Wilten Nicola and 2 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Neilen RasiahHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Tamás FüzesiHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Ewandson L LameuHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Nicolas F LandgrafHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0009-0003-9134-6575
David RoseneggerHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Spencer P LoewenHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-4372-8291
Toni-Lee SterleyHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Ibukun AkinrinadeHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Thomas L KashDepartment of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, US.ORCID http://orcid.org/0000-0002-4747-4495
Wilten NicolaHotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
Nuria Daviu *Hotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada. ndaviuab@uoguelph.ca.ORCID http://orcid.org/0000-0002-9843-2981
Jaideep S Bains *Hotchkiss Brain Institute, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada. jaideep.bains@uhn.ca.ORCID http://orcid.org/0000-0002-3634-6463

Funding

Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 30410
6 · The paper itself

Abstract

Maintaining appropriate behavioral and physiological responses in the face of challenge is essential for survival. The persistent increase in corticosteroids (CORT) during chronic stress blunts the endocrine response to any subsequent stressors. But the impact of prolonged CORT on behaviors that promote survival in the face of an acute stress is not well understood. Here we used an aerial predator threat model combined with in vivo calcium imaging, whole-cell electrophysiology, chemogenetics and computational modeling to evaluate the effects of short and long-term CORT. We show that in the short term, the activity of the corticotropin releasing hormone neurons of the paraventricular nucleus of the hypothalamus (CRH

Indexed as

CorticosteroneAnimalsBehavior, AnimalCorticotropin-Releasing HormoneFeedback, PhysiologicalGlutamic AcidHomeostasisMaleMiceMice, Inbred C57BLNeuronsParaventricular Hypothalamic NucleusStress, PsychologicalSynapsesCorticosteroneCorticotropin-Releasing HormoneGlutamic Acid

Identifiers

PMID41444404
PMCPMC13099376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.