Evidence map›Paper›PMID 41444387›Full record

ArticleJournal of human hypertension2026

Serum levels of placenta growth factor, adiponectin and endothelin-1 correlate to the occurrence and outcomes of hypertensive disorders complicating pregnancy.

Shasha Liu, Qianyu Lan, Weiling Li, Yuan Li, Jiefang Zhang, Liman Fu, Yanlei Xu

Abstract read
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Article in Journal of human hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shasha Liu *Department of General Internal Medicine, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Qianyu Lan *Department of General Internal Medicine, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Weiling LiDepartment of General Internal Medicine, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Yuan LiDepartment of General Internal Medicine, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Jiefang ZhangDepartment of General Internal Medicine, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Liman FuDepartment of Ultrasound, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China.
Yanlei XuDepartment of Obstetrics, the Fourth Hospital of Shijiazhuang, No.16 Tangu North Street, Shijiazhuang, 050031, Hebei, China. xuyanlei2024@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum placenta growth factor (PIGF), adiponectin, and endothelin-1 (ET-1) were associated with hypertension. However, it remains unclear whether these factors could predict the occurrence and prognosis of hypertensive disorders complicating pregnancy (HDCP). The enrolled pregnant women were classified into different groups according to diagnosis criteria. The demographic and clinical characteristics were compared among different groups. The levels of serum PIGF, adiponectin and ET-1 were determined. The predictive values of serum PIGF, adiponectin, and ET-1 for the occurrence and prognosis of HDCP were assessed using the receiver operating characteristic curve (ROC) analysis. There was a significant difference in systolic blood pressure, diastolic blood pressure, and proteinuria between the HDCP group and the normal pregnancy group. The level of serum PIGF and adiponectin decreased while ET-1 increased in the HDCP group compared to the normal pregnancy group. Furthermore, they had a similar change pattern with the progression of HDCP. The ROC analysis demonstrated that PIGF, adiponectin and ET-1 could effectively predict the occurrence and prognosis of HDCP. Compared to normal pregnant women, serum PIGF and adiponectin gradually decreased while ET-1 gradually increased with the progression of HDCP. Thus, they could effectively predict the occurrence and prognosis of HDCP.

Indexed as

AdiponectinEndothelin-1Hypertension, Pregnancy-InducedAdultBiomarkersBlood PressureCase-Control StudiesFemaleHumansPlacenta Growth FactorPregnancyPrognosisROC CurveAdiponectinADIPOQ protein, humanBiomarkersEndothelin-1PGF protein, humanPlacenta Growth Factor

Identifiers

PMID41444387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.