ArticleScientific reports2025
Metabolic profiling revealed alterations associated with sedentary work in bus drivers.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Metabolic profiling of severe early childhood caries and black stain: pathway and biomarker discovery in 3-6-year-olds.Frontiers in molecular biosciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Sedentary behavior in the workplace has emerged as a critical public health concern, with bus drivers representing a high-risk group due to prolonged compulsory sitting. This study aimed to investigate metabolic alterations associated with sedentary work in professional bus drivers compared to active controls. A total of 60 bus drivers and 60 sanitation workers (matched for age, sex, and lifestyle) as controls were enrolled. Fasting serum samples of the subjects were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for metabolomic profiling. Demographic data and biochemical parameters were also collected. Metabolomic analysis identified 322 metabolites, with 57 differential metabolites (52 up-regulated and 5 down-regulated) in the bus drivers relative to the controls, based on criteria of variable important for the projection value (VIP) ≥ 1, fold change ≥ 1.2 or ≤ 0.83, and P < 0.05. Pathway enrichment analysis revealed significant perturbations in metabolic pathways, including valine, leucine and isoleucine biosynthesis; 2-oxocarboxylic acid metabolism; and biosynthesis of amino acids. Additionally, biochemical analysis showed higher triglyceride levels in the bus drivers (P = 0.037). These findings highlight distinct metabolic signatures associated with prolonged sedentary work in bus drivers, providing insights into potential mechanisms linking occupational sedentary behavior to adverse health outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.