ArticleNature communications2025
Local peptide signalling induces stomatal closure under drought stress.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Plant peptide hormones: three decades of discovery and emerging paradigms.Plant physiology · 2026Review
- Signaling by a tyrosine-sulfated peptide balances growth and osmotic stress response in rice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Impact of Drought on Cereals Infected withPathogens (Basel, Switzerland) · 2026Review
- An IDA peptide from Boea hygrometrica enhances desiccation tolerance but lacks activity in Arabidopsis.Planta · 2026Article
- Novel roles of sulfur metabolism in stress-controlled stomata aperture regulation.The New phytologist · 2026Review
- A CLE11b-CLE16 Signaling Relay Mediates Root-Shoot-Root Crosstalk for Drought Adaptation in Common Bean.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
In response to drought stress, land plants close their stomata to minimize transpiration. This action precedes a gradual accumulation of the stress hormone abscisic acid (ABA) that enhances plant drought tolerance. However, the molecular mechanisms that cause the time lag between the onset of stomatal closure and ABA accumulation and coordinate these two phases remain unexplained. Here, we found that Arabidopsis thaliana loss-of-function CLAVATA3/ENDOSPERM SURROUNDING REGION 5 (CLE5) mutants are less tolerant to drought. The CLE5 dodecapeptide (CLE5p) acts as a local signal to induce stomatal closure by binding to the LEUCINE-RICH REPEAT RECEPTOR-LIKE KINASE (LRR-RLK) receptor complex, BARELY ANY MERISTEM 1 (BAM1)-GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1 (GHR1), in guard cells. The BAM1-GHR1-CLE5p module directly phosphorylates two SNF1-related protein kinases, OPEN STOMATA1 (SRK2E) and SRK2D, the central regulators of drought responses in plants, to regulate stomatal movement and drought-responsive gene expression without stimulating ABA biosynthesis or ROS accumulation. Our findings mark a critical step in understanding how plants promptly counteract environmental stresses. The CLEp-LRR-RLK signalling components are highly conserved across plant phyla, suggesting that peptide-mediated rapid stomatal closure is a widespread survival strategy and can be exploited to generate drought-resistant crops.
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