Evidence map›Paper›PMID 41443867›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Aspiration Pneumonia with Herpes Simplex Encephalitis in an Elderly Japanese Patient.

Ayaka Harada, Yuichiro Iwamoto, Yoshiro Fushimi, Akiko Saito, Ryota Satake, Junpei Sanada, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Masahito Mihara and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ayaka HaradaDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Yuichiro IwamotoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Yoshiro FushimiDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Akiko SaitoDepartment of Neurology, Kawasaki Medical School, Japan.
Ryota SatakeDepartment of Neurology, Kawasaki Medical School, Japan.
Junpei SanadaDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Tomohiko KimuraDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Masashi ShimodaDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Shuhei NakanishiDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
Masahito MiharaDepartment of Neurology, Kawasaki Medical School, Japan.
Hideaki KanetoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 94-year-old woman residing in a nursing home was admitted with aspiration pneumonia. A sputum culture yielded Klebsiella pneumoniae. Despite appropriate management, the patient's mental status deteriorated. Brain magnetic resonance imaging demonstrated high signal intensity in the right insular cortex on diffusion-weighted images, raising the suspicion of limbic encephalitis. A lumbar puncture revealed clear cerebrospinal fluid (CSF) with normal cell counts and protein levels. On hospital day 5, HSV-1 DNA was detected in the CSF, confirming herpes simplex encephalitis (HSE), and acyclovir was initiated. In elderly patients with unexplained altered consciousness, clinicians should not exclude HSE based on normal CSF findings.

Indexed as

Encephalitis, Herpes SimplexPneumonia, AspirationAcyclovirAged, 80 and overAntiviral AgentsDNA, ViralEast Asian PeopleFemaleHerpesvirus 1, HumanHumansJapanAcyclovirAntiviral AgentsDNA, Viralaspiration pneumoniaFilmArrayherpes simplex encephalitisnormocellular CSF

Identifiers

PMID41443867
PMCPMC13561555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.